Herb Paris has been used as a medicinal plant as far back as ancient Greece and the Italian physician and botanist Matthiolus (Pietro Andrea Mattioli 1500-1577) referred to it as a good remedy against boils.
As a treatment for neck abscesses, the root was either eaten raw or a tincture was made from the berries that were then brushed on the affected area or used as a gargle.
Herb Paris (Paris quadrifolia) – Illustration
In folk medicine, the leaves were once used as a compress on ulcers and slow healing wounds and the berries were used to expel bedbugs.
In the past, the herb was also used to treat rabies (hydrophobia), and the berries were used as a remedy against the plague. In some places in Russia, the leaves were prescribed for insanity. Probably because the plant has some narcotic effect.